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Video instructions and help with filling out and completing Publication 1494 2022
Hi Tara shiny felt for UAB School of Medicine in this video I'm going to discuss one the major threats to the validity of a systematic review namely publication bias I'll discuss what publication bias is and give a very general overview of ways that we can try to detect its presence before we get started with this video I really want to make a disclaimer that this is a very general overview of publication bias and not met for systematic reviewers to get an in-depth discussion of methods used to detect and analyze for publication bias so publication bias is just one type of reporting bias and I'd like you to pause this video review this slide and see some of the different things that affect the decision to publish or not publish a study that go beyond what editorial boards consider when you've done restart the video so don't you find it interesting that there's lots of different things that go into decision of publishing a paper publication bias is just one of them so what is publication bias so really it's the tendency to submit or accept a study depending on the studies results and largely what it means is that positive studies tend to get published more than negative studies and some people call this the file drawer problem where studies that are negative or not as strong as the researchers were like never get submitted for publication they're stuck in a file drawer never to see the light of day so there's a couple of studies that have shown evidence of publication bias I'd like to show you here this is one review that looked at the publication rates of significant versus non significant results and these are a variety of studies that each analyzed that significant findings are these dark black bars the white bars are non significant or studies that had no difference and as you can see by the black bar is a greater percentage of studies that have significant results get published compared to non significant results so that's evidence of publication bias this was an interesting study published in the British Medical Journal a decade ago which looked at studies submitted to the Swedish equivalent of the FDA for approval of a variety of SSRI drugs and these red and blue circles are the studies done by the drug companies in support of their drug that were submitted to the Swedish FDA and any publications arising from them are above it in these green diamonds now the red circles are studies that showed significant effects the blue studies are are the blue circles of studies that showed non significant effects and I think what you can see when you look at the rates of publication there are more publications from red studies which were significant effects then from the blue one so this is again evidence of significant publication bias so why does publication bias even matter well remember.